4-(2-tert-Butoxy-2-oxoethoxy)benzoic acid → HCID 59437534, compound

HRID 2382836Notes

Reaction equation

HRID 2382836 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH2:15])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1.[C:16]([O:20][C:21](=[O:33])[CH2:22][O:23][C:24]1[CH:32]=[CH:31][C:27]([C:28](O)=[O:29])=[CH:26][CH:25]=1)([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21](=[O:33])[CH2:22][O:23][C:24]1[CH:25]=[CH:26][C:27]([C:28]([NH:15][C:13]2[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=[C:6]([C:3]4[CH:4]=[CH:5][O:1][CH:2]=4)[N:11]3[N:12]=2)=[O:29])=[CH:31][CH:32]=1)([CH3:19])([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 211804184-(2-tert-Butoxy-2-oxoethoxy)benzoic acidHCID 252159385-(Furan-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 59437534HCID 59437534, compound

Procedure

The title compound was prepared following procedure and work up described for example 2, but starting from 5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A2), 75 mg; 0.37 mmol; 1.0 eq.) and 4-(2-t-butoxy-2-oxoethoxy)benzoic acid (113 mg; 0.45 mmol; 1.2 eq.) as a white foam (21.6 mg, 13%). HPLC, Rt: 3.98 min. (purity 98.3%). LC/MS, M+(ESI): 435.1, M−(ESI): 433.1.

Sources & evidence

ORD record
ord-f0338d29d5b845d880e348fef23af5cf
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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