Hydrochloric Acid → (2-Piperidin-4-yl-phenyl)-methanol hydrochloride

Participants

Reaction Steps

4-(4-(2-Hydroxymethyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (0.13 g, 0.44 mmol) was dissolved in a solution of hydrogen chloride in dioxane (4 N, 2 mL). The mixture was stirred for 1 hour and the solvent removed by evaporation under vacuum. The solid was triturated from ether to afford the title compound as a white solid (0.08 g). LCMS m/z 192.2 [M+H]+. R.T.=0.72 min (Analytical Method 4).

Provenance & Evidence