4-Amino-1-methylpiperidine → HCID 25214467, compound

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Reaction Steps

The title compound was prepared following procedure and work up described for example 71 but starting from N-(5-chloro[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzamide ((B3), 100 mg; 0.37 mmol; 1.0 eq.) and 4-amino-1-methyl-piperidine (ABCR, 0.50 mL) as a white powder (59 mg, 46%). 1H NMR (DMSO-d6) δ 10.91 (brs, 1H), 8.00 (d, J=7.2 Hz, 2H), 7.57 (m, 4H), 6.87 (d, J=8.3 Hz, 1H), 6.49 (d, J=8.3 Hz, 1H), 6.29 (d, J=7.9 Hz, 1H), 3.84 (m, 1H), 2.74 (m, 2H), 2.16 (s, 3H), 2.03 (m, 2H), 1.92 (m, 2H), 1.66 (m, 2H). HPLC, Rt: 1.70 min. (purity 99.4%). LC/MS, M+(ESI): 351.4, M−(ESI). 349.4.

Provenance & Evidence