Cycloheptylamine → HCID 25214470, compound

HRID 2382856Notes

Reaction equation

HRID 2382856 reaction equation
Cl[C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[N:15][CH:14]=3)[N:10]=[C:6]2[CH:5]=[C:4]([C:20]([F:23])([F:22])[F:21])[CH:3]=1.[CH:24]1([NH2:31])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[CH:24]1([NH:31][C:2]2[N:7]3[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]4[CH:18]=[CH:17][CH:16]=[N:15][CH:14]=4)[N:10]=[C:6]3[CH:5]=[C:4]([C:20]([F:23])([F:22])[F:21])[CH:3]=2)[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 2899CycloheptylamineHCID 25212520HCID 25212520, compound

Product 1

HCID 25214470HCID 25214470, compound

Procedure

The title compound was prepared following procedure described for example 71 at rt but starting from N-[5-chloro-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]nicotinamide ((B7), 50 mg; 0.14 mmol; 1.0 eq.) and cycloheptylamine (1.0 mL) as a white powder (8 mg, 13%). HPLC, Rt: 3.85 min. (purity 95.9%). LC/MS, M+(ESI): 419.3, M−(ESI): 417.4.

Workup

  1. customdescribed for example 71 at rt

Sources & evidence

ORD record
ord-1f5d8e28b061406594b2b27e87572a45
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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