HCID 25212520, compound → HCID 178501196, compound

HRID 2382869Notes

Reaction equation

HRID 2382869 reaction equation
Cl[C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[N:15][CH:14]=3)[N:10]=[C:6]2[CH:5]=[C:4]([C:20]([F:23])([F:22])[F:21])[CH:3]=1.Cl.[CH3:25][O:26][C:27]([C@H:29]1[CH2:34][CH2:33][C@H:32]([NH2:35])[CH2:31][CH2:30]1)=[O:28]>>[N:15]1[CH:16]=[CH:17][CH:18]=[C:13]([C:12]([NH:11][C:9]2[N:10]=[C:6]3[CH:5]=[C:4]([C:20]([F:23])([F:22])[F:21])[CH:3]=[C:2]([NH:35][C@H:32]4[CH2:31][CH2:30][C@H:29]([C:27]([O:26][CH3:25])=[O:28])[CH2:34][CH2:33]4)[N:7]3[N:8]=2)=[O:19])[CH:14]=1

Participants

3

Reactant 2

HCID 25212520HCID 25212520, compoundHCID 178501210HCID 178501210, compound

Product 1

HCID 178501196HCID 178501196, compound

Procedure

The title compound was prepared following procedure described for example 85, but starting from N-[5-chloro-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]nicotinamide ((B7), 50 mg; 0.15 mmol; 1.0 eq.) and trans-4-amino-cyclohexylcarboxylic acid methyl ester hydrochloride (IRIS), 52 μl; 0.73 mmol; 5.0 eq.) as a white powder (23 mg, 34%). HPLC, Rt: 3.33 min. (purity 96.4%). LC/MS, M+(ESI): 463.1, M−(ESI): 461.1.

Sources & evidence

ORD record
ord-7f37a62b56d14d8190dbce0f84d9ad53
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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