rac-((1R,2R)-2-aminocyclohexyl)methanol hydrochloride → N-[5-{[(1RS,2RS)-2-(hydroxymethyl)cyclohexyl]amino}-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]nicotinamide

Participants

Reaction Steps

The title compound was prepared following procedure described for example 85, but starting from N-[5-chloro-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]nicotinamide ((B7), 50 mg; 0.15 mmol; 1.0 eq.) and trans-2-hydroxymethyl-1-cyclohexylamine hydrochloride (121 mg; 0.73 mmol; 5.0 eq.) as a white solid (32 mg, 50%). HPLC, Rt: 3.00 min. (purity 89.6%). LC/MS, M+(ESI): 435.1, M−(ESI): 433.0.

Provenance & Evidence