Sec-Butylamine → HCID 59437500, compound

HRID 2382875Notes

Reaction equation

Cl[C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[N:15][CH:14]=3)[N:10]=[C:6]2[CH:5]=[C:4]([C:20]([F:23])([F:22])[F:21])[CH:3]=1.[CH:24]([NH2:28])([CH2:26][CH3:27])[CH3:25]>>[CH:24]([NH:28][C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[N:15][CH:14]=3)[N:10]=[C:6]2[CH:5]=[C:4]([C:20]([F:23])([F:22])[F:21])[CH:3]=1)([CH2:26][CH3:27])[CH3:25]

Participants

Reactant 2

HCID 24874Sec-Butylamine

HCID 25212520HCID 25212520, compound

Product 1

HCID 59437500HCID 59437500, compound

Procedure

The title compound was prepared following procedure and work up described for example 85 but starting from N-[5-chloro-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]nicotinamide ((B7), 50 mg; 0.15 mmol; 1.0 eq.) and sec-butylamine (53.50 mg; 0.73 mmol; 5.0 eq.) as a white solid (4 mg, 7%). HPLC, Rt: 3.44 min. (purity 89.4%). LC/MS, M+(ESI): 379.1, M−(ESI): 377.0.

Sources & evidence

ORD record: ord-6815cd944b5748abae33de72d4f9059a
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08263595B2

Reaction notes

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