反应详情

温度

55 °C

A mixture of pyridin-3-ylacetyl chloride (120.07 mg; 0.77 mmol; 1.50 eq.) and N5-cyclohexyl[1,2,4]triazolo[1,5-a]pyridine-2,5-diamine ((A9); 119 mg; 0.51 mmol; 1.0 eq.) in DCM (1 mL) in presence of pyridine (1244; 1.54 mmol; 3 eq.) was heated in a sealed tube at 55° C. for 3 h. Et2O and Water were then added to the mixture, the precipitate obtained was filtered, washed with water, Et2O, Acetonitrile and dried under vacuum at 40° C. to give the title compound as an off-white powder (74 mg, 41%). HPLC, Rt: 2.49 min. (purity 98.0%). LC/MS, M+(ESI): 350.9, M−(ESI): 348.9.

1. customthe precipitate obtained
2. filtrationwas filtered
3. washwashed with water, Et2O, Acetonitrile
4. customdried under vacuum at 40° C.