3-Amino-1-propanol → HCID 59437560, compound

Participants

Reaction Steps

To a biotage initiator microwave vial (0.2-0.5 mL) containing 6-chloro-N-(5-cyclohexylamino-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-nicotinamide ((B11), 0.27 mmol, 100 mg, 1 eq.), 3-aminopropan-1-ol (0.54 mmol, 0.028 mL, 2 eq.) and N,N-diisopropylethylamine (0.54 mmol, 0.094 mL, 2 eq.) in butanol (2 mL), was capped and heated in a biotage initiator 60 microwave for 30 minutes at 180° C., and a further 10 minutes at 210° C. The solvent was removed in vacuo and the residue dissolved in DMSO (1.5 mL) and purified by reverse phase preparatory HPLC to give the title compound as a white solid (33.4 mg, 30%). HPLC, Rt: 2.37 min (purity: 92%). LC/MS M+(ESI): 410.2, M−(ESI) 408.2.

Provenance & Evidence