HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2382935Generated: October 27, 2026
1,3-Cyclohexadiene → 4-(Aminomethyl)-N-methylbenzene-1-sulfonamide
https://huagongshe.com/reaction/2382935
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,3-Cyclohexadiene | HCID 11605 | — |
| Reactant | 4-azidomethyl-N-methyl-benzenesulfonamide | HCID 59667981 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(Aminomethyl)-N-methylbenzene-1-sulfonamide | HCID 16460978 | — |
Reaction Steps
A mixture of 4-azidomethyl-N-methyl-benzenesulfonamide (2.20 g, 10.0 mmol), cyclohexadiene (8.90 mL, 90.0 mmol) and palladium hydroxide (20% on carbon, 1.4 g, 2.0 mmol) in MeOH (20 mL) was warmed at 65° C. for 2 hours. The solution was cooled to room temperature and filtered through diatomaceous earth. The solvent was removed in vacuo to afford 4-aminomethyl-N-methyl-benzenesulfonamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08263597B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-1cbcb44ce13b4734af822844787912fb |
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| Source note | uspto-grants-2012_09 |
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