HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid | HCID 58138774 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid chloride | HCID 58138874 | — |
Reaction Steps
To a solution of 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid (0.400 g, 1.56 mmol) in CH2Cl2 (5 mL) at room temperature was added oxalyl chloride (0.86 mL, 1.7 mmol) followed by DMF (20 μL). Gas evolution was observed. After 30 minutes, the solution was concentrated in vacuo to afford 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid chloride which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08263597B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-6c8abf9b1eaa4ef1bdae335d11c32f71 |
| Source note | uspto-grants-2012_09 |