Potassium Hydroxide → HCID 178497596, compound

Participants

Reaction Steps

To a solution of 1H-indazole-4-carboxylic acid methyl ester (380 mg, 2.2 mmol) in DMF (5 mL) was added N-bromosuccinimide (NBS) (976 mg, 4.32 mmol) and KOH (485 mg, 8.64 mmol). After 1 hour, the reaction mixture was diluted with saturated aqueous ammonium chloride (20 mL) and extracted with ethyl acetate (3×20 mL). The combined organic layers were washed with saturated aqueous sodium bicarbonate and brine (20 mL), dried over sodium sulfate and concentrated in vacuo to afford the title compound as a solid.

Provenance & Evidence