Hydantoin → HCID 68822728, compound

HRID 238297Notes

Reaction equation

HRID 238297 reaction equation
Cl[CH2:2][CH:3]=[CH:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[N:9]=1.[NH:17]1[CH2:21][C:20](=[O:22])[NH:19][C:18]1=[O:23]>>[F:16][C:13]1[CH:14]=[CH:15][C:10]([C:8]2[N:9]=[C:5]([CH:4]=[CH:3][CH2:2][N:19]3[C:20](=[O:22])[CH2:21][NH:17][C:18]3=[O:23])[S:6][CH:7]=2)=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 10006HydantoinHCID 688217062-(3-Chloroprop-1-en-1-yl)-4-(4-fluorophenyl)-1,3-thiazole

Product 1

HCID 68822728HCID 68822728, compound

Procedure

The compound was prepared analogously to example 3e) from 92 mg (0.36 mmol) of 2-(3-chloropropenyl)-4-(4-fluorophenyl)thiazole and 54.4 mg (0.54 mmol) of imidazolidine-2,4-dione. Yield: 31 mg (27%).

Sources & evidence

ORD record
ord-f361af9624c546d58d4900235f900cb5
Source dataset
uspto-grants-2014_02
Patent number
US08642620B2

Reaction notes

Loading…