HCID 57863259, compound → HCID 57863250, compound

Participants

Reaction Conditions

Reaction Steps

The crude 1-benzyl-N,N-dimethyl-2′,3′-dihydro-1′H-spiro[piperidine-4,4′-quinoline]-1′-carboxamide 2ab (3.1 g, 8.01 mmol) was dissolved in 30 mL absolute ethanol, flushed with nitrogen, and treated with 500 mg of 10% Pd/C. The flask was flushed with nitrogen then fitted with an H2 balloon. The rapidly stirring solution was heated to 45° C. overnight. The reaction was filtered through Celite and concentrated to yield N,N-dimethyl-2′,3′-dihydro-1′H-spiro[piperidine-4,4′-quinoline]-1′-carboxamide 2ac as an amber oil. LC/MS (10-99% CH3CN/0.05% TFA gradient over 5 min): m/z 274.2, retention time 1.39 minutes.

Provenance & Evidence