Tetrahydrofuran → HCID 49788936, compound

Participants

Reaction Steps

To a solution of acid 45 (137 mg, 0.61 mmol) in DIEA (213 μL, 1.22 mmol) and anhydrous THF (8 mL), cooled at 0° C., EDCI (175 mg, 0.09 mmol) and HOBT-NH3 (137 mg, 0.9 mmol) were added and the solution was stirred overnight at rt. The solution was concentrated, water was added and the product was extracted with DCM. The organic layer was washed with water, dried and concentrated to give a solid that was triturated with Et2O to afford 50 mg (44%) of 5-pyridin-4-yl-1H-pyrrole-3-carboxylic Acid Amide.

Provenance & Evidence