1-Methylpiperazine → HCID 57659326, compound

Participants

Reaction Steps

A mixture of ester 50 (30 mg, 0.08 mmol, obtained as described in Example 1), Pd(OAc)2 (1 mg, 0.0045 mmol), (2-biphenylyl)dicyclohexylphosphine (3 mg, 0.008 mmol), tBuONa (16 mg, 0.17 mmol), 1-methylpiperazine (60 μL, 0.54 mmol), in toluene (1 mL) and anhydrous DMF (0.2 mL) was subdued to the action of microwaves at 130° C. for 20 min. After filtration on celite and aqueous work-up (EtOAc/water) the crude 2-[4-(4-methyl-piperazin-1-yl)-phenyl]-5-pyridin-4-yl-1H-pyrrole-3-carboxylic acid ethyl ester was obtained.

Provenance & Evidence