Ditoluoyltartaric acid, (+)- → (1S)-1-(2-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline (2s,3s)-2,3-bis[(4-methylbenzoyl)oxy]succinate

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Reaction Steps

1-(2-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline (8.227 g) and (2S,3S)-2,3-bis[(4-methybenzoyl)oxy]succinic acid (13.282 g) were dissolved with stirring in acetonitrile (246 mL) at 70° C. The mixture was slowly cooled with stirring. The resulting crystal was collected by filtration, washed with acetonitrile, and dried under reduced pressure to obtain (1S)-1-(2-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline (2S,3S)-2,3-bis[(4-methylbenzoyl)oxy]succinate (16.193 g).

Provenance & Evidence