Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → HCID 86621313, compound

Participants

Reaction Steps

5.045 g (27.12 mmol) of 6-bromopyridine-3-carbaldehyde were dissolved in 50 ml of THF. 9.068 g (27.12 mmol) of 2-(triphenylphosphoranylidene)acetic acid methyl ester were added and the mixture was stirred at RT for 4 hours. After evaporation, the residue stirred with methanol and the solid was filtered off. The filtrate was evaporated and the residue was purified by chromatography (silica gel, ethyl acetate/n-heptane 1:4). Yield: 5.01 g (76.3%)

Provenance & Evidence