反应详情

温度

150 °C

Phosphoric acid (11.9 mL) was added to diphosphorus pentoxide (20.0 g) over 5 minutes. The mixture was stirred at 150° C. for 0.5 hours. 3-fluoro-N-(2-phenylethyl)benzamide (5.00 g) was added to the mixture, followed by stirring at 160° C. for 2.5 hours. After cooling, water was added to the reaction solution to which 28% aqueous ammonia was then added to be alkaline. The reaction solution was extracted with EtOAc, washed with saturated brine, and dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure to obtain 1-(3-fluorophenyl)-3,4-dihydroisoquinoline (4.87 g).

1. stirringby stirring at 160° C. for 2.5 hours
2. temperatureAfter cooling
3. additionwas then added
4. extractionThe reaction solution was extracted with EtOAc
5. washwashed with saturated brine
6. dry with materialdried over magnesium sulfate
7. filtrationAfter filtration
8. concentrationthe filtrate was concentrated under reduced pressure