Phosphorus oxide (P4O10) → HCID 67537538, compound

Participants

Reaction Conditions

Reaction Steps

N-[2-(2-methylphenyl)ethyl]butanamide (4.58 g) was dissolved in xylene (30 mL), and then diphosphorus pentoxide (10 g) was added thereto, followed by stirring at 140° C. for 4 hours. The reaction mixture was left to cool and then the solvent was evaporated. An aqueous 8 M potassium hydroxide solution, water, and chloroform were used to dissolve completely the insoluble materials. The reaction mixture was adjusted to a pH of around 8, and extracted with chloroform. The extract was washed with saturated brine, and then dried over magnesium sulfate. The solvent was evaporated under reduced pressure and the resulting residue was purified by silica gel column chromatography (hexane-EtOAc) to obtain 5-methyl-1-propyl-3,4-dihydroisoquinoline (2.14 g).

Provenance & Evidence