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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2383047Generated: October 29, 2026

2-Benzyl-1-(1-methoxy-1-methylethyl)-1,2,3,4-tetrahydroisoquinoline → 1-(1-Methoxy-1-methylethyl)-1,2,3,4-tetrahydroisoquinoline

https://huagongshe.com/reaction/2383047

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Benzyl-1-(1-methoxy-1-methylethyl)-1,2,3,4-tetrahydroisoquinolineHCID 59396480—
CatalystPalladiumHCID 23938—
SolventMethanolHCID 887—
Product1-(1-Methoxy-1-methylethyl)-1,2,3,4-tetrahydroisoquinolineHCID 5939658494.7%

Reaction Steps

10% palladium-supported carbon (300 mg) was added to a solution of 2-benzyl-1-(1-methoxy-1-methylethyl)-1,2,3,4-tetrahydroisoquinoline (1.17 g) in MeOH (12 mL). The reaction material was stirred under a hydrogen atmosphere at room temperature for 8 hours. The reaction liquid was filtered through celite and the filtrate was concentrated under reduced pressure to obtain 1-(1-methoxy-1-methylethyl)-1,2,3,4-tetrahydroisoquinoline (770 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08263607B2
Source datasetuspto-grants-2012_09
ORD IDord-b34ac9b7fa3d4d91b036c939e3317781
Source noteuspto-grants-2012_09