HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2383075Generated: October 27, 2026
2-((3-Methylbutyl)amino)ethan-1-ol → 2-[[3-(1-cyclohexyl-3,4-dihydroisoquinolin-2(1H)-yl)-3-oxopropyl](3-methylbutyl)amino]ethanol
https://huagongshe.com/reaction/2383075
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-((3-Methylbutyl)amino)ethan-1-ol | HCID 278477 | — |
| Reactant | 2-Acryloyl-1-cyclohexyl-1,2,3,4-tetrahydroisoquinoline | HCID 59396622 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2-[[3-(1-cyclohexyl-3,4-dihydroisoquinolin-2(1H)-yl)-3-oxopropyl](3-methylbutyl)amino]ethanol | HCID 59396632 | 28.8% |
Reaction Steps
2-(isopentylamino)-ethanol (26 mg) was added to a solution of 2-acryloyl-1-cyclohexyl-1,2,3,4-tetrahydroisoquinoline (7 mg) in iPrOH (0.1 mL), followed by stirring at 90° C. for 10 hours. Thereafter, the reaction liquid was purified by preparative HPLC to obtain 2-[[3-(1-cyclohexyl-3,4-dihydroisoquinolin-2(1H)-yl)-3-oxopropyl](3-methylbutyl)amino]ethanol (3 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08263607B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-afe7e67085cf4e3fba9ad2ef8b2b708f |
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| Source note | uspto-grants-2012_09 |
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