Ethyl orthopropionate → 8-benzyloxy-2-ethyl-1-methyl-1H-imidazo[4,5-c]quinoline

Participants

Reaction Steps

The general method described in Part A of Example 47 was followed using 6-benzyloxy-N4-methylquinoline-3,4-diamine (7.91 g, 28.3 mmol) in lieu of 7-benzyloxy-N4-(2-phenoxyethyl)quinoline-3,4-diamine and triethyl orthopropionate (12.69 mL, 56.6 mmol) in lieu of trimethyl orthovalerate. The precipitate from the reaction was isolated in two crops to provide 7.56 g of 8-benzyloxy-2-ethyl-1-methyl-1H-imidazo[4,5-c]quinoline as a yellow solid, mp 168.2-169.0° C.

Provenance & Evidence