5H,6H,7H,8H-imidazo(1,5-a)pyridin-8-one → HCID 66933758, compound

HRID 2383247Notes

Reaction equation

HRID 2383247 reaction equation
[CH:1]1[N:2]=[CH:3][N:4]2[CH2:9][CH2:8][CH2:7][C:6](=[O:10])[C:5]=12.[C:11]1([Mg]Br)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[C:11]1([C:6]2([OH:10])[CH2:7][CH2:8][CH2:9][N:4]3[CH:3]=[N:2][CH:1]=[C:5]23)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 167520695H,6H,7H,8H-imidazo(1,5-a)pyridin-8-oneHCID 178418255HCID 178418255, compound

Product 1

HCID 66933758HCID 66933758, compound

Procedure

In analogy to Example 3a 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one [426219-51-4] and phenylmagnesium bromide solution [100-58-3] (1M in tetrahydrofuran) are reacted. The title compound is obtained as a beige solid. Rt=4.10 (Gradient I).

Sources & evidence

ORD record
ord-86490f51807644ae92e2568738f0f127
Source dataset
uspto-grants-2012_09
Patent number
US08263615B2

Reaction notes

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