4-Iodopyridine → 8-Pyridin-4-yl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

HRID 2383248Notes

Reaction equation

[CH:1]1[N:2]=[CH:3][N:4]2[CH2:9][CH2:8][CH2:7][C:6](=O)[C:5]=12.I[C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1>>[N:15]1[CH:16]=[CH:17][C:12]([CH:6]2[CH2:7][CH2:8][CH2:9][N:4]3[CH:3]=[N:2][CH:1]=[C:5]23)=[CH:13][CH:14]=1

Participants

Reactant 2

HCID 6094924-Iodopyridine

HCID 167520695H,6H,7H,8H-imidazo(1,5-a)pyridin-8-one

Product 1

HCID 669337678-Pyridin-4-yl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

Procedure

In analogy to Example 1 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one [426219-51-4] and 4-iodopyridine [15854-87-2] are reacted. The title compound is obtained as a light brown foam. Rt=2.26 (Gradient I).

Sources & evidence

ORD record: ord-bc8c8325ea3a421c880b1c31d7d885f8
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08263615B2

Reaction notes

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