Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | HCID 86650601 | HCID 86650601 | — |
| Catalyst | Zinc cyanide (Zn(CN)2) | HCID 11186 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Product | HCID 57814375 | HCID 57814375 | — |
Reaction Steps
1.03 mmol of trifluoromethanesulphonic acid 4-(7,7-dimethyl-5,6,7,8-tetrahydroimidazo-[1,5-a]pyridin-8-yl)phenyl ester and 2.06 mmol of zinc(II) cyanide are introduced under argon in 10 ml of absolute N,N-dimethylformamide. The reaction mixture is admixed with 0.05 mmol of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium and stirred at 120° C. for 20 hours. The reaction mixture is poured into ice-water and extracted with tert-butyl methyl ether (3×). The combined organic phases are dried with magnesium sulphate and evaporated. From the residue the title compound is obtained by means of flash chromatography (SiO2 60 F) as a pale pink solid. Rf=0.17 (dichloromethane/ammonia (2M in EtOH) 97:3), Rf=5.40 (Gradient I).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08263615B2 |
|---|
| Source dataset | uspto-grants-2012_09 |
|---|
| ORD ID | ord-55df5159b3204f40a00bc6071a0f4c16 |
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| Source note | uspto-grants-2012_09 |
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