反应详情

A solution of 3.50 mmol of 8-(4-methoxyphenyl)-7,7-dimethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyridin-8-ol in 10 ml of ethanol is admixed with 3.5 mmol of concentrated sulphuric acid and 0.70 mmol of 10% Pd/C and the reaction mixture is hydrogenated in an autoclave at 4 bar and 60° C. for 4-8 hours. The reaction mixture is filtered over Hyflo and the filtrate is concentrated. The title compound is used without further purification for the next stage. Rt=5.89 (Gradient I).

1. filtrationThe reaction mixture is filtered over Hyflo
2. concentrationthe filtrate is concentrated
3. customThe title compound is used without further purification for the next stage