HCID 86647994, compound → HCID 68734582, compound

Participants

Reaction Steps

1,1-dimethylethyl[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,3,4-tetrahydro-1-isoquinolinyl]acetate (Preparation 5, 61 mg, 0.126 mmol) was stirred at room temperature for 18 hours in 4M HCl in 1,4-Dioxane (10 mL). Evaporation yielded the title compound (54 mg). 1H NMR (400 MHz, d6-DMSO)) δ 8.19 (1H, s), 8.11 (1H, d), 8.00 (1H, d), 7.61 (1H, d), 7.54 (1H, t), 7.46 (1H, d), 4.96-4.86 (2H, m), 1.37 (6H, d), other aliphatic signals obscured by solvent peaks; m/z (API-ES) 428, 430 [M+H]+.

Provenance & Evidence