Trifluoroacetic acid → HCID 68771174, compound

Participants

Reaction Conditions

Reaction Steps

Trifluoroacetic acid (1.0 ml, 13.0 mmol) was added dropwise at 25° C. under nitrogen to a solution of 4-(6-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2-{[(1,1-dimethylethyl)oxy]carbonyl}-5-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl)butanoic acid (Preparation 31; 95 mg, 0.167 mmol) in dichloromethane (4.0 ml) and the resulting mixture was stirred at 25° C. for 45 min. The solvent was removed and the residue co-evaporated with toluene followed by trituration with diethyl ether to give the title compound (70 mg) as a white solid.

Provenance & Evidence