Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | HCID 67309113 | HCID 67309113 | — |
| Catalyst | Zinc cyanide (Zn(CN)2) | HCID 11186 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | HCID 67309639 | HCID 67309639 | — |
Reaction Steps
A suspension of 2-(4-bromonaphthalene-2-yl)-4-methylthiazole-5-carboxylic acid ethyl ester (0.050 g), zinc cyanide (0.031 g) and tetrakis(triphenylphosphine)palladium (0.015 g) in N-methylpyrrolidone (2 mL) was stirred at 150° C. for 50 minutes using microwave reactor (Biotage). To the reaction mixture was added water (15 mL), and the precipitated solid was collected by filtration, and washed with water and n-hexane to give 2-(4-cyanonaphthalene-2-yl)-4-methylthiazole-5-carboxylic acid ethyl ester (0.042 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08263622B2 |
|---|
| Source dataset | uspto-grants-2012_09 |
|---|
| ORD ID | ord-c0a06d997fbc412ea6fadefed3839776 |
|---|
| Source note | uspto-grants-2012_09 |
|---|
