反应详情

Tert-butyl 4-({3-[(R)-cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperidin-1-carboxylate (Preparation 3a, 2.00 g, 4.40 mmol) was dissolved in dioxane (11 ml) and stirred vigorously to achieve solubilisation. 4M HCl in dioxane (5.54 mL, 22.1 mmol) was then added. After stirring at room temperature for 24 hours the solvent was removed in vacuo, and the residue partitioned between dichloromethane (50 mL) and saturated aqueous sodium bicarbonate solution (50 mL). The organic layer was separated, dried over magnesium sulphate, filtered and the solvent removed in vacuo to furnish the title compound as a colourless oil, in 96% yield, 1.5 g.

1. stirringAfter stirring at room temperature for 24 hours the solvent
2. customwas removed in vacuo
3. customthe residue partitioned between dichloromethane (50 mL) and saturated aqueous sodium bicarbonate solution (50 mL)
4. customThe organic layer was separated
5. dry with materialdried over magnesium sulphate
6. filtrationfiltered
7. customthe solvent removed in vacuo