反应详情

温度

90 °C

Cyclohexyl-phenyl-(1-piperidin-4-ylmethyl-1H-[1,2,4]triazol-3-yl)-methanol (Preparation 4, 8.2 g, 2.98 mmol), 2-{2-[4-(2-Bromo-ethyl)-phenyl]-ethyl}-isoindole-1,3-dione (Preparation 11, 7.56 g, 21.1 mmol), and triethylamine (13.3 ml, 95.9 mmol) were dissolved in acetonitrile (100 ml). After stirring at 90° C. for 48 hours the solvent was removed in vacuo, and the residue partitioned between dichloromethane (200 ml) and water (200 mL). The organic layer was separated, dried over magnesium sulphate, filtered and the solvent removed in vacuo. The residue was purified by column chromatography on silica gel eluting with dichloromethane:methanol:880 ammonia (98:2:0.2, by volume) and the resulting material then triturated in tert-butyl methyl ether to furnish title compound as a clear solid in 28% yield, 3.4 g.

1. customwas removed in vacuo
2. customthe residue partitioned between dichloromethane (200 ml) and water (200 mL)
3. customThe organic layer was separated
4. dry with materialdried over magnesium sulphate
5. filtrationfiltered
6. customthe solvent removed in vacuo
7. customThe residue was purified by column chromatography on silica gel eluting with dichloromethane
8. custommethanol:880 ammonia (98:2:0.2, by volume) and the resulting material then triturated in tert-butyl methyl ether