反应详情

Cyclohexyl(phenyl)[1-(pyrrolidin-1-ylmethyl)-1H-1,2,4-triazol-5-yl]methanol (Preparation 17, 27.28 g, 80.12 mmol) was dissolved in ethanol (400 ml) and sodium borohydride (3.03 g, 80.1 mmol) added portionwise. After stirring at reflux for 3 hours the reaction was left to cool to room temperature over 18 hrs. The solvent was removed in vacuo and the residue purified by column chromatography on silica gel eluting with pentane:ethyl acetate (3:1 to 0:1, by volume) to furnish the title compound as a white foam, in 79% yield, 16.4 g.

1. temperatureat reflux for 3 hours the reaction
2. waitwas left
3. customThe solvent was removed in vacuo
4. customthe residue purified by column chromatography on silica gel eluting with pentane:ethyl acetate (3:1 to 0:1, by volume)