Ammonium formate → Diphenyl[1-(piperidin-4-ylmethyl)-1H-1,2,4-triazol-3-yl]methanol

Participants

Reaction Steps

Benzyl 4-({3-[hydroxy(diphenyl)methyl]-1H-1,2,4-triazol-1-yl}methyl)piperidine-1-carboxylate (Preparation 25, 5.2 g, 16.78 mmol) was dissolved in ethanol (300 ml) and ammonium formate (6 g) and palladium hydroxide [20 wt. % (dry basis) on carbon (wet)] (1 g) added. After stirring at reflux for 1 hour the reaction mixture was cooled to room temperature and filtered through Arbocel®. The solvent was removed in vacuo and the residue partitioned between dichloromethane (500 ml) and water (500 mL). The aqueous layer was separated and then basified with aqueous sodium hydroxide solution (2N, 200 ml) and extracted with dichloromethane (500 ml). This organic layer was then dried over magnesium sulphate, filtered and the solvent removed in vacuo. The crude material was recrystallised from acetonitrile to furnish the title compound as a white solid, in 51% yield, 1.9 g.

Provenance & Evidence