2-{2-[4-(2-Bromo-ethyl)-phenyl]-ethyl}-isoindole-1,3-dione → 2-[2-(4-{2-[4-({3-[hydroxy(diphenyl)methyl]-1H-1,2,4-triazol-1-yl}methyl)piperidin-1-yl]ethyl}phenyl)ethyl]-1H-isoindole-1,3(2H)-dione

Participants

Reaction Steps

The title compound was prepared from diphenyl[1-(piperidin-4-ylmethyl)-1H-1,2,4-triazol-3-yl]methanol (Preparation 26, 778 mg, 2.23 mmol) and 2-{2-[4-(2-bromoethyl)phenyl]ethyl}-1H-isoindole-1,3(2H)-dione (Preparation 11, 800 mg, 2.23 mmol) using the same method as described in preparation 12, to give a white solid, in 71% yield, 1.00 g.

Provenance & Evidence