反应详情

A solution of thiocarbamate (12.2 mmol) in chloroform (10 mL) was added dropwise over a period of 40 min to a vigorously maintained mixture of ethyl 3-[aminocarbonothioyl)amino]benzoate (5.78 mmol), glacial acetic acid (10 mL) and chloroform (10 mL). The mixture was maintained 30 min at rt and then was heated at 70° C. for 4 h. The mixture was allowed to cool to room temperature and maintained for an additional 13 h. The volatiles were removed under reduced pressure and the solid residue was suspended in a mixture of chloroform (10 mL) and acetone (10 mL). The product was isolated by filtration, washed successively with acetone (5 mL) and hexanes (10 mL), and dried in a vacuum oven, thus providing the product in 95% yield as a mixture of ethyl 2-amino-1,3-benzothiazole-7-carboxylate hydrobromide and ethyl 2-amino-1,3-benzothiazole-5-carboxylate hydrobromide in a ratio of 95/5, respectively. This product was partitioned between saturated aqueous solution of sodium bicarbonate (25 mL) and a mixture of ethyl acetate (70 mL) and tetrahydrofuran (30 mL). The organic layer was separated, dried over anhydrous sodium sulfate and concentrated. The residue was crystallized form ethyl acetate, thus providing pure ethyl 2-amino-1,3-benzothiazole-7-carboxylate. 1H NMR (500 MHz, Me2SO-d6) δ 1.35 (t, J=7.5, 3H), 4.36 (q, J=7, 2H), 7.35 (t, J=7.5, 1H), 7.57 (d, J=7, 1H), 7.61 (bs, 2H), 7.65 (d, J=8, 1H); MS (EI) m/z 223 (M++1).

1. temperaturewas heated at 70° C. for 4 h
2. temperatureto cool to room temperature
3. temperaturemaintained for an additional 13 h
4. customThe volatiles were removed under reduced pressure
5. additionthe solid residue was suspended in a mixture of chloroform (10 mL) and acetone (10 mL)
6. customThe product was isolated by filtration
7. washwashed successively with acetone (5 mL) and hexanes (10 mL)
8. customdried in a vacuum oven
9. customthus providing the product in 95% yield
10. customThis product was partitioned between saturated aqueous solution of sodium bicarbonate (25 mL)
11. additiona mixture of ethyl acetate (70 mL) and tetrahydrofuran (30 mL)
12. customThe organic layer was separated
13. dry with materialdried over anhydrous sodium sulfate
14. concentrationconcentrated
15. customThe residue was crystallized form ethyl acetate