2-(3-Isocyanatophenoxy)-6-methylpyrazine → N-{3-[(6-methylpyrazin-2-yl)oxy]phenyl}-3,6,8,9-tetrahydro-7H-pyrazolo[3,4-c][2,7]naphthyridine-7-carboxamide

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Reaction Steps

The compound, N-{3-[(6-methylpyrazin-2-yl)oxy]phenyl}-3,6,8,9-tetrahydro-7H-pyrazolo[3,4-c][2,7]naphthyridine-7-carboxamide was prepared using 6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-7-ium 2,2,2-trifluoroacetate and 2-(3-isocyanatophenoxy)-6-methylpyrazine as described in general procedure M. The product was obtained as a white solid; 400 MHz 1H NMR (DMSO-d6) δ: 13.59 (s, 1H), 8.86 (s, 2H), 8.34 (s, 1H), 8.3-8.25 (m, 2H), 8.17 (s, 1H), 7.4-7.26 (m, 3H), 6.8-6.74 (m, 1H), 4.77 (s, 2H), 3.82 (t, J=5.6 Hz, 2H), 3.14 (t, J=5.6 Hz, 2H), 2.35 (s, 3H); LCMS [M+H]: 402.

Provenance & Evidence