Trifluoroacetic acid → HCID 59490394, compound

Participants

Reaction Conditions

Reaction Steps

To N-[3-(4-methoxy-benzyl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c]isoquinolin-7-yl]-benzamide (0.084 g, 0.21 mmol) was added trifluoroacetic acid (2 mL). The reaction mixture was heated at 65° C. for 16 hours. On completion of the reaction, toluene (5 mL) was added and the solvent removed under reduced pressure. The crude product was purified using reverse phase HPLC to give the desired product, N-(6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c]isoquinolin-7-yl)benzamide as a white solid (0.015 g, 25%). M.p.>300° C.; 400 MHz 1H NMR (DMSO-d6) δ: 13.31 (s, 1H), 8.49 (d, J=7.2 Hz, 1H), 8.00 (d, J=1.2 Hz, 1H), 7.92 (s, 1H), 7.86 (m, 2H), 7.48 (m, 3H), 4.28 (m, 1H), 3.22-2.91 (m, 4H), 2.13 (m, 1H), 1.96 (m, 1H); LCMS [M+H]: 293.

Provenance & Evidence