Trifluoroacetic acid → Trifluoroacetic acid

Participants

Reaction Steps

To a solution of 1-[3-(tert-butoxycarbonylamino-methyl)-phenyl]-3,6,8,9-tetrahydro-pyrazolo[3,4-c][2,7]naphthyridine-7-carboxylic acid tert-butyl ester (0.07 g, 0.14 mmol) in dichloromethane (5 mL) was added trifluoroacetic acid (1 mL). The mixture was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure and purified by reverse phase HPLC to give the desired product, 3-(6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-1-yl)-benzylamine as a bis TFA salt and as a white solid (0.046 g, 62%). 1H NMR (400 MHz, DMSO-d6) δ13.98 (s, 1H), 9.27 (brs, 2H), 8.45 (s, 1H), 8.30 (brs, 2H), 7.70 (s, 1H), 7.58 (m, 3H), 4.44 (s, 2H), 4.14 (m, 2H), 3.31 (m, 2H), 3.01 (m, 2H); LC-Mass: m/e 480.73 (M+H).

Provenance & Evidence