N-Methylisobutylamine → HCID 69047517, compound

Participants

Reaction Conditions

Reaction Steps

5 ml of (4-bromophenoxy)-t-butyldimethylsilane, 2.9 ml of isobutylmethylamine, 458.0 mg of palladium acetate, 1.2 g of 2-(di t-butylphosphino)biphenyl and 2.9 g of sodium t-butoxide were suspended in 40 ml of anhydrous toluene, and the mixture was stirred at 100° C. for 1.5 hours. The catalyst was filtered, followed by addition of water and extraction with ethyl acetate. After the extraction solution was washed with saturated saline and dried over anhydrous sodium sulfate, the solvent was distilled off, and the resulting residue was purified by silica gel column chromatography (eluting solvent: ethyl acetate/n-hexane=1/40→1/20) to give the title compound (3.83 g, 64% yield).

Provenance & Evidence