HCID 58055039, compound → HCID 68026894, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-nitrophenyl (2S)-1,1,1-trifluoropropan-2-yl carbonate (15 mg) prepared in Referential Example 2 in CHCl3 (2 mL) was added tert-butyl (3aR,6aR)-3a-methoxyhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate (11 mg) at room temperature. The resulting mixture was stirred at 100° C. in a sealed tube for 2 hours and then cooled to room temperature. The mixture was purified with silica gel column chromatography (eluent: hexane/EtOAc=1/0˜0/1) to give 5-tert-butyl 1-[(2S)-1,1,1-trifluoropropan-2-yl] (3aR,6aR)-3a-methoxyhexahydropyrrolo[3,4-b]pyrrole-1,5-dicarboxylate as a pale yellow foam.

Provenance & Evidence