Acetone Cyanohydrin → 2-Methyl-2-(morpholin-4-yl)propanenitrile

HRID 2383671Notes

Reaction equation

HRID 2383671 reaction equation
[CH3:1][C:2]([CH3:6])(O)[C:3]#[N:4].[NH:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1>CC(C)=O>[CH3:1][C:2]([N:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1)([CH3:6])[C:3]#[N:4]

Participants

4

Reactant 2

HCID 6406Acetone CyanohydrinHCID 8083Morpholine

Product 1

HCID 24237842-Methyl-2-(morpholin-4-yl)propanenitrile

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Acetone cyanohydrin (4.3 g, 50 mmol) was dissolved into acetone (5 mL). Morpholine (4.3 g, 50 mmol) was added and the solution was stirred at rt for 24 h. The volatile solvents were removed in vacuo to give the title compound as a clear liquid in quantitative yield. MS ESI 155.0 [M+H]+, calcd for [C8H14N2O+H]+ 155.1.

Workup

  1. customThe volatile solvents were removed in vacuo

Sources & evidence

ORD record
ord-b6fad58712f2476fb1f3631502250128
Source dataset
uspto-grants-2012_09
Patent number
US08263596B2

Reaction notes

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