Tetrahydrofuran → HCID 86684881, compound

Participants

Reaction Steps

Under cooling in an ice bath, potassium carbonate (148 mg) was added to a tetrahydrofuran (16 mL) and methanol (36 mL) solution of 1-methyl-5-[4-(trifluoromethyl)phenyl]-4-[(trimethylsilyl)ethynyl]-1H-pyrazole (3.45 g), and the obtained solution was then stirred for 4.5 hours. Thereafter, the reaction solution was filtrated with Celite, and the filtrate was then concentrated under a reduced pressure. The residue was diluted with ethyl acetate, and was then washed with a saturated ammonium chloride aqueous solution. The organic layer was dried over anhydrous sodium sulfate, and was then concentrated under a reduced pressure. The residue was purified by column chromatography (silica gel 60N, hexane:ethyl acetate=85:15 to 60:40), so as to obtain the title compound (2.31 g).

Provenance & Evidence