反应详情

温度

90 °C

10% NaOH solution (10 mL) was added to a solution of 1-(4-methyl-pyridin-3-yl)-3-[1-(toluene-4-sulfonyl)-1H-indol-6-yl]-imidazolidin-2-one (I-144a: 94 mg) in ethanol (10 mL). The resulting mixture was heated to reflux at 90° C. for 1 hour. The reaction was monitored by TLC (10% MeOH in CHCl3). The reaction mixture was concentrated and partitioned between ethylacetate and water. The organic layer was washed with water, brine solution, dried and concentrated. Purification by column chromatography on silica gel (2% MeOH in DCM) afforded 29 mg of the product (47.54% yield).

1. temperatureThe resulting mixture was heated
2. concentrationThe reaction mixture was concentrated
3. custompartitioned between ethylacetate and water
4. washThe organic layer was washed with water, brine solution
5. customdried
6. concentrationconcentrated
7. customPurification by column chromatography on silica gel (2% MeOH in DCM)