Hydrochloric Acid → HCID 86684887, compound

Participants

Reaction Steps

Under a nitrogen atmosphere, 1.0 M diisobutylaluminum hydride (1.70 mL, toluene solution) was added dropwise to a tetrahydrofuran (5.0 mL) solution of 4-[(5-formyl-1-methyl-1H-pyrazol-4-yl)ethynyl]benzenesulfonamide (160 mg) at −78° C., and the obtained solution was then stirred for 1 hour. Thereafter, water was added to the reaction solution, and the obtained solution was converted to an acidic solution by addition of 2 M hydrochloric acid. Then, the solution was extracted with ethyl acetate. The organic layer was washed with water, and was then dried over anhydrous sodium sulfate, followed by vacuum concentration. The residue was purified by column chromatography (silica gel cartridge, chloroform/methanol=99:1 to 95:5), so as to obtain the title compound (60 mg) in the form of a light yellow solid.

Provenance & Evidence