HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[4-(Cyclopropyl-hydroxy-methyl)-3-fluoro-phenyl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one → 1-(4-Cyclopropanecarbonyl-3-fluoro-phenyl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[4-(Cyclopropyl-hydroxy-methyl)-3-fluoro-phenyl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one | HCID 59636141 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(4-Cyclopropanecarbonyl-3-fluoro-phenyl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one | HCID 59636140 | 60.13% |
Reaction Steps
MnO2 (357 mg, 41.055 mmol) was added to 1-[4-(cyclopropyl-hydroxy-methyl)-3-fluoro-phenyl]-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-161a: 200 mg, 8.586 mmol) in DCM (20 mL) under nitrogen atmosphere and worked up in a manner similar to what has been described previously for example 160 (Step 2) to afford 175 mg of the product (60.13% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08263635B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-8247326a2c4c4fc88465bcf60f339535 |
| Source note | uspto-grants-2012_09 |