Hydrochloric Acid → HCID 86635827, compound

Participants

Reaction Steps

At room temperature and under nitrogen, to a solution of 2-chloro-6-cyano-6-(4-methoxy-dibenzofuran-1-yl)-1-oxa-spiro[2.5]octane-2-carboxylic acid methyl ester (0.300 g, 0.0007 mol) (as obtained in step 1) in a mixture of ethanol (5 ml) and water (0.15 ml) was added sodium methoxide (0.190 g, 0.0035 mol). The reaction mass was refluxed for 1 hr, and once the product has formed, the reaction mass was brought to room temperature and the pH was adjusted to 2 with dil. HCl and extracted with Ethyl acetate. The organic layer was dried with sodium sulfate and concentrated under vacuum to get the 2-chloro-6-cyano-6-(4-methoxy-dibenzofuran-1-yl)-1-oxa-spiro[2.5]octane-2-carboxylic acid. Yield 0.180 g (64%)

Provenance & Evidence