Water → HCID 24804128, compound

Participants

Reaction Conditions

Reaction Steps

At room temperature, to a solution of the epoxy acid (0.380 g, 0.0009 mol) (as formed in step 2) in DMSO (8 ml)/Water (0.8 ml) sodium chloride (0.055 g, 0.000.9 mol) was charged and the reaction mass was heated to 100° C. for 7 hrs. Once the product has formed, the reaction mass was quenched with water and extracted with ethyl acetate. The organic layer was dried with sodium sulfate and concentrated under vacuum. 4-cyano-4-(4-methoxy-dibenzofuran-1-yl)-cyclohexane carboxylic acid was isolated by column chromatography. Yield 0.035 g, (10.8%)

Provenance & Evidence