反应详情

温度

65 °C

To a stirred solution of sodium methoxide (185.3 mg, 3.5 mmol) in 10 ml of methanol was added formamidine acetate (290 mg, 2.78 mmol) and the compound obtained in example 1. The reaction mass was allowed to stir at 60-70° C. for 18 hrs under nitrogen atmosphere. Most of the methanol was evaporated under vacuum and residue was purified by column chromatography to get 200 mg (67.3% yields) of the product.

1. customMost of the methanol was evaporated under vacuum and residue
2. customwas purified by column chromatography
3. customto get
4. custom200 mg (67.3% yields) of the product