反应详情

To a stirred solution of the compound obtained in example 19 (100 mg, 0.2188 mmol) in 4 ml of ethanol was added 1N NaOH solution (3 ml) and the reaction mass was allowed to stir at room temperature for 4 hrs. The reaction mass was diluted with 20 ml water and washed 3 timed with 25 ml diethyl ether. The aqueous layer was acidified with 1N aq. HCl to pH 2-3 and extracted with chloroform. The organic layer was washed with water followed by brine, and concentrated under vacuum. The residue was triturated with ether to give 45 mg (Yields-48%) of product.

1. washwashed 3
2. extractionextracted with chloroform
3. washThe organic layer was washed with water
4. concentrationconcentrated under vacuum
5. customThe residue was triturated with ether
6. customto give
7. custom45 mg (Yields-48%) of product